Potassium Carbonate → 1-(6-Bromo-7-(2-(2-methoxyethoxy)ethoxy)-2-benzothiazolyl)-3-ethyl-urea

HRID 9115

반응식

HRID 9115 반응식
[Br:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[S:8][C:4]=2[C:3]=1[OH:17].C(=O)([O-])[O-].[K+].[K+].[CH3:24][O:25][CH2:26][CH2:27][O:28][CH2:29][CH2:30]Br>CN(C=O)C>[Br:1][C:2]1[CH:16]=[CH:15][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[S:8][C:4]=2[C:3]=1[O:17][CH2:30][CH2:29][O:28][CH2:27][CH2:26][O:25][CH3:24]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 1235321-Bromo-3,6-dioxaheptaneHCID 219855951-(6-Bromo-7-hydroxy-2-benzothiazolyl)-3-ethylurea

생성물 1

HCID 219855411-(6-Bromo-7-(2-(2-methoxyethoxy)ethoxy)-2-benzothiazolyl)-3-ethyl-urea수율 39%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea 6, potassium carbonate and 2-(2-methoxyethoxy)ethyl bromide in DMF was reacted to give 0.026 g (39%) of the desired compound 12. 1H NMR (DMSO) δ 10.65 (br s, 1H, NH), 7.54 (d, 1H, J=8.5 Hz, ArH), 7.32 (d, 1H, J=8.6 Hz, ArH), 6.73 (br s, 1H, NH), 4.24 (d, 2H, J=4.4 Hz, CH2), 3.76 (d, 2H, J=4.8 Hz, CH2), 3.61 (dd, 2H, J=6.0, 5.2 Hz, CH2), 3.48 (dd, 2H, J=6.0, 5.2 Hz, CH2), 3.26 (s, 3H CH3), 3.19 (m, 2H, CH2), 1.09 (t, 3H, J=7.1 Hz, CH3); LC/MS 418 (MH+); RP-HPLC RT 2.95 minutes.

후처리

  1. customwas reacted

출처 및 근거

ORD 기록
ord-6994d4027fca4d73947eb9301277e302
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091227B2

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