Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 1-(6-Bromo-7-(4-fluoro-benzyloxy)-2-benzothiazolyl)-3-ethyl-urea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Fluorobenzyl bromide | HCID 68021 | — |
| 반응물 | 1-(6-Bromo-7-hydroxy-2-benzothiazolyl)-3-ethylurea | HCID 21985595 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-(6-Bromo-7-(4-fluoro-benzyloxy)-2-benzothiazolyl)-3-ethyl-urea | HCID 21985631 | 19% |
반응 단계
A mixture of 1-(6-bromo-7-hydroxy-2-benzothiazolyl)-3-ethyl-urea 6, potassium carbonate and p-fluoro-benzyl-bromide in DMF was reacted to give 0.013 g (19%) of the desired compound 13. 1H NMR (DMSO) δ 1.08 (t, 3H, J=8 Hz CH2CH3), 3.18 (m, 2H, CH2), 5.16 (s, 2H, OCH2Ar), 6.73 (br s, 1H, NH), 7.26 (dd, 2H, J=4, 4 Hz, ArH),7.36 (d, 1H, J=8 Hz, ArH), 7.56 (d, 1H, J=4 Hz, ArH), 7.58 (d, 2H, J=4 Hz, ArH), 10.89 (br s, 1H, NH). HPLC retention time 3.61 minutes.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091227B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-6778be28994349a58c0ea43b72428dba |
| 출처 메모 | uspto-grants-2006_08 |