참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Propanal | HCID 527 | — |
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | 3,5-Dimethyl-4-nitroisoxazole | HCID 261410 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | HCID 66995125 | HCID 66995125 | 225% |
반응 단계
3,5-dimethyl-4-nitroisoxazole (2.50 g, 17.6 mmol) in 25 mL EtOH was dissolved. Piperidine (0.174 mL, 1.76 mmol) was added followed by propionaldehyde (1.52 mL, 21.1 mmol). The solution was heated at 90° C. overnight. The solution was concentrated and chromatographed using EtOAc to obtain the title compound (0.650 g, 22.5% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08022223B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_09 |
|---|
| ORD ID | ord-a9d4ad6753aa4fba9ae239735904992f |
|---|
| 출처 메모 | uspto-grants-2011_09 |
|---|
