Propanal → HCID 66995125, 화합물

HRID 911821

반응식

HRID 911821 반응식
[CH3:1][C:2]1[C:6]([N+:7]([O-:9])=O)=[C:5]([CH3:10])[O:4][N:3]=1.N1CC[CH2:14][CH2:13][CH2:12]1.C(=O)CC>CCO>[CH3:1][C:2]1[C:6]2=[N+:7]([O-:9])[C:13]([CH3:14])=[CH:12][CH:10]=[C:5]2[O:4][N:3]=1

참가 물질

5

반응물 3

HCID 527PropanalHCID 8082PiperidineHCID 2614103,5-Dimethyl-4-nitroisoxazole

생성물 1

HCID 66995125HCID 66995125, 화합물수율 225%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
90 °C

실험 절차

3,5-dimethyl-4-nitroisoxazole (2.50 g, 17.6 mmol) in 25 mL EtOH was dissolved. Piperidine (0.174 mL, 1.76 mmol) was added followed by propionaldehyde (1.52 mL, 21.1 mmol). The solution was heated at 90° C. overnight. The solution was concentrated and chromatographed using EtOAc to obtain the title compound (0.650 g, 22.5% yield).

후처리

  1. concentrationThe solution was concentrated
  2. customchromatographed

출처 및 근거

ORD 기록
ord-a9d4ad6753aa4fba9ae239735904992f
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022223B2

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