Water → ethyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate N-oxide

HRID 911828노트

반응식

HRID 911828 반응식
C1C=C(Cl)C=C(C(OO)=[O:9])C=1.[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]2[CH2:18][N:19]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:20][C:13]=12.O>C(Cl)Cl>[N+:12]1([O-:9])[CH:17]=[CH:16][CH:15]=[C:14]2[CH2:18][N:19]([C:21]([O:23][CH2:24][CH3:25])=[O:22])[CH2:20][C:13]=12

참가 물질

5

반응물 3

HCID 962WaterHCID 70297m-Chloroperbenzoic acidHCID 18953634ethyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate

생성물 1

HCID 66995055ethyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate N-oxide수율 74%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

mCPBA (7.3 g, 30 mmol) was added into a solution of ethyl 5H-pyrrolo[3,4-b]pyridine-6(7H)-carboxylate (5 g, 26 mmol) in CH2Cl2 (200 mL) and stirred for 2 hours. The reaction was poured into water and extracted with CH2Cl2. The organic layer was washed with aqueous sodium bisulfate, NaHCO3 and brine, dried with Na2SO4, filtered and concentrated to afford the title compound (4 g, 74% yield) as a white solid.

후처리

  1. extractionextracted with CH2Cl2
  2. washThe organic layer was washed with aqueous sodium bisulfate, NaHCO3 and brine
  3. dry with materialdried with Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-994d3f1bd6844b47ac1a9eb8826fe50a
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022223B2

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