1-(3-(Trifluoromethoxy)phenyl)ethanone → 1-[3-(Trifluoromethoxy)phenyl]ethan-1-ol
반응식
[F:1][C:2]([F:14])([F:13])[O:3][C:4]1[CH:5]=[C:6]([C:10](=[O:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1.[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1.O>[F:1][C:2]([F:13])([F:14])[O:3][C:4]1[CH:5]=[C:6]([CH:10]([OH:12])[CH3:11])[CH:7]=[CH:8][CH:9]=1참가 물질
5
실험 절차
To a solution of 1-(3-Trifluoromethoxyphenyl)ethanone (1.00 g, 4.90 mmol) in THF (5 mL) at 0° C. was added 1M LiAlH4 in THF (5.9 mL, 5.9 mmol), and the solution was allowed to warm to rt. A few drops of water were added to quench. The mixture was concentrated in vacuo, transferred to a separatory funnel, and extracted using DCM and sat. aq. Rochelle salt. The organic layer was concentrated in vacuo to afford the title compound as a clear oil.
후처리
- customto quench
- concentrationThe mixture was concentrated in vacuo
- customtransferred to a separatory funnel
- extractionextracted
- concentrationThe organic layer was concentrated in vacuo
출처 및 근거
- ORD 기록
- ord-49adbfd6985c447db28fbb4e3494241a
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08022206B2
반응 노트
불러오는 중…