(4-Ethylpiperazin-1-yl)-(4-methyl-3-nitrophenyl)methanone → 5-[(4-Ethylpiperazin-1-YL)carbonyl]-2-methylaniline

HRID 912154

반응식

HRID 912154 반응식
[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([N+:18]([O-])=O)[CH:12]=2)=[O:10])[CH2:5][CH2:4]1)[CH3:2]>CO.[C].[Pd]>[CH2:1]([N:3]1[CH2:8][CH2:7][N:6]([C:9]([C:11]2[CH:16]=[CH:15][C:14]([CH3:17])=[C:13]([NH2:18])[CH:12]=2)=[O:10])[CH2:5][CH2:4]1)[CH3:2]

참가 물질

4

반응물 1

HCID 808340(4-Ethylpiperazin-1-yl)-(4-methyl-3-nitrophenyl)methanone

생성물 1

HCID 167887345-[(4-Ethylpiperazin-1-YL)carbonyl]-2-methylaniline수율 105.8%

시약·촉매·용매 2

HCID 178418390HCID 178418390, 화합물촉매HCID 887Methanol용매

실험 절차

(4-Ethyl-piperazin-1-yl)-(4-methyl-3-nitro-phenyl)-methanone (1.06 g, 3.82 mmol) obtained in Step A was stirred for 16 hours in methanol (20 ml) under a hydrogen atmosphere in the presence of 10% palladium carbon. After the reaction mixture was filtered, the filtrate was concentrated under reduced pressure, to obtain (4-ethyl-piperazin-1-yl)-(3-amino-4-methyl-phenyl)-methanone (1.0 g, quant.).

후처리

  1. filtrationAfter the reaction mixture was filtered
  2. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-9e2899b8544e4cc8836a451aa78a67ff
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022205B2

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