Morpholine → Morpholino(3-nitrophenyl)methanone

HRID 912225

반응식

[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([OH:9])=O)([O-:3])=[O:2].[NH:13]1[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1>>[N:13]1([C:7]([C:6]2[CH:10]=[CH:11][CH:12]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=2)=[O:9])[CH2:18][CH2:17][O:16][CH2:15][CH2:14]1

참가 물질

반응물 2

HCID 8083Morpholine

HCID 84973-Nitrobenzoic acid

생성물 1

HCID 225453Morpholino(3-nitrophenyl)methanone

실험 절차

Using 3-nitro-benzoic acid (334 mg) and morpholine (209 μl) instead of 1-ethyl-piperazine, in the same manner as Step A in Example 1-D-101, the desired compound was obtained (340 mg, 72%).

출처 및 근거

ORD 기록: ord-2223697611574dd79c62bcbc3ae4d340
출처 데이터셋: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08022205B2

연결된 노트

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