Morpholine → [3,5-Difluoro-4-(4-methoxy-benzylamino)-phenyl]-morpholin-4-yl-methanone

HRID 912343노트

반응식

HRID 912343 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([F:21])[C:10]=1[NH:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1)[C:5]([OH:7])=O.[NH:22]1[CH2:27][CH2:26][O:25][CH2:24][CH2:23]1>>[F:21][C:9]1[CH:8]=[C:4]([C:5]([N:22]2[CH2:27][CH2:26][O:25][CH2:24][CH2:23]2)=[O:7])[CH:3]=[C:2]([F:1])[C:10]=1[NH:11][CH2:12][C:13]1[CH:18]=[CH:17][C:16]([O:19][CH3:20])=[CH:15][CH:14]=1

참가 물질

3

반응물 2

HCID 8083MorpholineHCID 592447773,5-Difluoro-4-(4-methoxy-benzylamino)-benzoic acid

생성물 1

HCID 59244740[3,5-Difluoro-4-(4-methoxy-benzylamino)-phenyl]-morpholin-4-yl-methanone

실험 절차

Using 3,5-difluoro-4-(4-methoxy-benzylamino)-benzoic acid (95.4 mg) obtained in Step B in Example 1-D-24 and morpholine (33.8 μl) instead of 1-ethyl-piperazine, in the same manner as Step C in Example 1-D-24, the desired compound was obtained as a crude product (111 mg, 94%).

출처 및 근거

ORD 기록
ord-9ddcad69ceb94f2e8828ebcf9f0f0bd5
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08022205B2

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