참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Dimethylamine | HCID 674 | — |
| 반응물 | Methyl 6-(hydroxymethyl)picolinate | HCID 11513809 | — |
| 생성물 | 6-(hydroxymethyl)-N,N-dimethylpicolinamide | HCID 59410646 | 103% |
반응 단계
Methyl 6-(hydroxymethyl)picolinate (0.598 mmol, 100 mg) was suspended in dimethylamine (2M in MeOH) (2.99 mmol, 1496 μl) and heated to 150° C. for 20 minutes in a microwave. Heating was repeated for a further 20 minutes then further dimethylamine (2M in MeOH) (2.99 mmol, 1496 μl) added and heating repeated again for 20 minutes. Solvent was evaporated under reduced pressure to yield 6-(hydroxymethyl)-N,N-dimethylpicolinamide (103% yield) as a clear oil. 1H NMR (CD3OD) δ: 7.95 (d, 1H), 7.82 (t, 1H), 7.50 (d, 1H), 4.75 (s, 2H), 2.73 (s, 6H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08026236B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_09 |
|---|
| ORD ID | ord-1dab7b5e83224f3188c10f57098557e1 |
|---|
| 출처 메모 | uspto-grants-2011_09 |
|---|
