Bromine → 2-Bromo-1-[2-(trifluoromethyl)phenyl]propan-1-one

HRID 912576노트

반응식

HRID 912576 반응식
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9](=[O:12])[CH2:10][CH3:11].[Br:15]Br>C(Cl)(Cl)(Cl)Cl>[Br:15][CH:10]([CH3:11])[C:9]([C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:2]([F:13])([F:14])[F:1])=[O:12]

참가 물질

4

반응물 2

HCID 24408BromineHCID 1400402-(Trifluoromethyl)propiophenone

생성물 1

HCID 201874742-Bromo-1-[2-(trifluoromethyl)phenyl]propan-1-one수율 95%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매2회

실험 절차

To a solution of 2′-trifluoromethyl-propiophenone (10 g, 48 mmol) in carbon tetrachloride (50 ml) was added a solution of bromine (2.72 mL, 52.8 mmol) in carbon tetrachloride (20 mL) dropwise. After the addition was complete, stirring was continued for another 2h. The solution was washed with satd NaHCO3 and water, dried (anhyd Na2SO4) and concentrated under reduced pressure to give 2-bromo-1-(2-trifluoromethyl-phenyl)-propan-1-one as an oil (12.8 g, 95%), which was used in the next step without purification. 1H-NMR (CDCl3): δ 7.73 (m, 2H), 7.58-7.67 (m, 2H), 4.96 (q, 1H), 1.90 (d, 3H). To a solution of 2′-trifluoromethyl-propiophenone (10 g, 48 mmol) in carbon tetrachloride (50 ml) was added a solution of bromine (2.72 mL, 52.8 mmol) in carbon tetrachloride (20 m

후처리

  1. additionAfter the addition
  2. washThe solution was washed with satd NaHCO3 and water
  3. dry with materialdried (anhyd Na2SO4)
  4. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-ca203ea7a7064ec5a1bed8c060c78038
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026237B2

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