HCID 67254019, 화합물 → Methyl 4-methyl-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxylate

HRID 912579노트

반응식

HRID 912579 반응식
[CH3:1][O:2][C:3]([CH:5]1[C:9]([CH3:10])=[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]([F:20])([F:19])[F:18])[NH:7][CH2:6]1)=[O:4]>C1(C)C=CC=CC=1.[Pd]>[CH3:1][O:2][C:3]([C:5]1[C:9]([CH3:10])=[C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[C:17]([F:20])([F:19])[F:18])[NH:7][CH:6]=1)=[O:4]

참가 물질

4

반응물 1

HCID 67254019HCID 67254019, 화합물

생성물 1

HCID 67251895Methyl 4-methyl-5-(2-(trifluoromethyl)phenyl)-1H-pyrrole-3-carboxylate수율 29.3%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 1140Toluene용매

실험 절차

To a solution of 4-methyl-5-(2-trifluoromethyl-phenyl)-2,3-dihydro-1H-pyrrole-3-carboxylic acid methyl ester (10 g, 35 mmol) in toluene was added 10% Pd/C (3.3 g). The resulting suspension was heated to reflux for 3 days. After cooling, the solids were removed by filtration. The filtrate was washed with toluene and concentrated under reduced pressure to yield an oil, which was purified by column chromatography (silica), eluting with EtOAc-hexane (1:1) to give the title compound (2.9 g, 29%). MS (ES): 284 (MH+).

후처리

  1. temperatureThe resulting suspension was heated
  2. temperatureto reflux for 3 days
  3. temperatureAfter cooling
  4. customthe solids were removed by filtration
  5. washThe filtrate was washed with toluene
  6. concentrationconcentrated under reduced pressure
  7. customto yield an oil, which
  8. customwas purified by column chromatography (silica)
  9. washeluting with EtOAc-hexane (1:1)

출처 및 근거

ORD 기록
ord-3eb8825f49d644e588555b10246ce8c4
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026237B2

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