참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl isocyanate | HCID 8022 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Amino-6-benzylbenzothiazole | HCID 21985510 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-(6-Benzyl-2-benzothiazolyl)-3-ethylurea | HCID 21985614 | 56% |
반응 단계
A suspension of 2-amino-6-benzyl-benzothiazole (0.040 g, 0.17 mmol), triethylamine (0.104 mL, 0.77 mmol, 4.5 eq), and ethyl isocyanate (0.049 mL, 0.64 mmol, 3.8 eq) in 1 mL toluene was heated at about 95° C. for about 16 hours. The precipitate was filtered off, washed with Et2O and MeOH, and dried under vacuum to give the desired compound 0.029 g (56%). LC/MS 312.3 (M+1); LC retention time 2.62 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07091227B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-507cd915806547c7b328f3dffb50e852 |
|---|
| 출처 메모 | uspto-grants-2006_08 |
|---|
