6-Butoxy-2-hydroxymethylpyridine → 6-Butoxypyridine-2-carbaldehyde

HRID 912700노트

반응식

HRID 912700 반응식
[CH2:1]([O:5][C:6]1[N:11]=[C:10]([CH2:12][OH:13])[CH:9]=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4]>ClCCl.[O-2].[O-2].[Mn+4]>[CH2:1]([O:5][C:6]1[N:11]=[C:10]([CH:12]=[O:13])[CH:9]=[CH:8][CH:7]=1)[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 1

HCID 197561166-Butoxy-2-hydroxymethylpyridine

생성물 1

HCID 108450736-Butoxypyridine-2-carbaldehyde수율 84%

시약·촉매·용매 2

HCID 178418406HCID 178418406, 화합물촉매HCID 6344Dichloromethane용매2회

실험 절차

Activated manganese dioxide (2.40 g, 27.6 mmol) was added to a solution of (6-butoxy-pyridin-2-yl)methanol (0.52 g, 2.85 mmol, obtained from Example 17(c)) in anhydrous dichloromethane (5 mL). The resulting solution was heated to reflux for 2 h and then cooled to r.t. and 50 mL of dichloromethane added. The black solid was removed by filtration through silica gel and washed with dichloromethane. The combined filtrate was concentrated in vacuo providing the title compound (0.43 mg, 84%) as a light yellow oil.

후처리

  1. temperatureThe resulting solution was heated
  2. temperatureto reflux for 2 h
  3. customThe black solid was removed by filtration through silica gel
  4. washwashed with dichloromethane
  5. concentrationThe combined filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-9c4665e5dd6149efb98ef77713b1b34c
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026244B2

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