참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 1-Bromo-4-fluorobenzene | HCID 9993 | — |
| 반응물 | Sodium hydride | HCID 24758 | — |
| 반응물 | Tert-butyl 4-hydroxypiperidine-1-carboxylate | HCID 643502 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | 1-BOC-4-(4-bromophenoxy)piperidine | HCID 46739006 | 98.2% |
반응 단계
A solution of 2.01 g (10 mmol) of 1,1-dimethylethyl 4-hydroxy-1-piperidinecarboxylate in 20 ml of dimethylformamide is admixed with 7 g (40 mmol) of 1-bromo-4-fluorobenzene and 2.5 g (50 mmol) of sodium hydride at 50% in mineral oil. The mixture is stirred at 100° C. for 3 hours and then evaporated to dryness. The residue is taken up in 50 ml of ice-water and extracted with dichloromethane. The organic extracts are evaporated to dryness, to give 3.5 g of an oily product, which is used as it is in the following step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08026258B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_09 |
|---|
| ORD ID | ord-0f140603e0394309894e324b9534237a |
|---|
| 출처 메모 | uspto-grants-2011_09 |
|---|
