1-Bromo-4-fluorobenzene → HCID 67415486, 화합물

HRID 912735노트

반응식

HRID 912735 반응식
[OH:1][CH2:2][CH:3]1[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]1.[Br:16][C:17]1[CH:22]=[CH:21][C:20](F)=[CH:19][CH:18]=1>>[Br:16][C:17]1[CH:22]=[CH:21][C:20]([O:1][CH2:2][CH:3]2[CH2:8][CH2:7][N:6]([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:5][CH2:4]2)=[CH:19][CH:18]=1

참가 물질

3

반응물 2

HCID 99931-Bromo-4-fluorobenzeneHCID 2764081Tert-butyl 4-(hydroxymethyl)piperidine-1-carboxylate

생성물 1

HCID 67415486HCID 67415486, 화합물수율 133.9%

실험 절차

The procedure described in Example 4.1. is repeated. Starting from 2.5 g (11.6 mmol) of 1,1-dimethylethyl 4-(hydroxymethyl)-1-piperidinecarboxylate and 8.13 g (46.4 mmol) of 1-bromo-4-fluorobenzene gives 5.75 g of crude product in oil form.

출처 및 근거

ORD 기록
ord-b45f461f548c47aa8fa5a3560acb950d
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026258B2

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