Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine → 4-Bromo-6-trifluoromethyl-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-(3-Chloro-5-(trifluoromethyl)pyridin-2-yl)piperazine | HCID 667619 | — |
| 반응물 | 4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole | HCID 11594585 | — |
| 생성물 | 4-Bromo-6-trifluoromethyl-2-[4-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole | HCID 57835199 | — |
반응 단계
The reaction of 1-(3-chloro-5-trifluoromethylpyridin-2-yl)piperazine (212 mg, 0.8 mmol, ABCR) and 4-bromo-2-chloro-6-trifluoromethyl-1H-benzoimidazole (210 mg, 0.7 mmol, Example 6b) under the conditions of Example 3c afforded the title compound as a white amorphous solid. MS (ESI, pos. ion) m/z: 530 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08026241B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-1761a859c26c420483a5b53fb92b448c |
| 출처 메모 | uspto-grants-2011_09 |