Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropylethylamine → 2-[4-(3-Chloropyridin-2-yl)piperazin-1-yl]-6-methyl-1H-benzoimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | 2-chloro-6-methyl-1H-1,3-benzodiazole | HCID 11629655 | — |
| 반응물 | 1-(3-Chloropyridin-2-yl)piperazine hydrochloride | HCID 20455074 | — |
| 생성물 | 2-[4-(3-Chloropyridin-2-yl)piperazin-1-yl]-6-methyl-1H-benzoimidazole | HCID 57835135 | — |
반응 단계
The reaction of 2-chloro-6-methyl-1H-benzoimidazole (0.202 g, 1.59 mmol, Example 14b), 1-(3-chloropyridin-2-yl)piperazine hydrochloride (0.373 g, 1.22 mmol, Example 3b) and N,N-diisopropylethylamine (0.56 mL, 3.2 mmol, Aldrich) under the conditions of Example 3c afforded the title compound as a white solid. M.p. 258-259° C. MS (ESI, pos. ion) m/z: 328 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08026241B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-e8f9cb03ad0f4689bfd3d1f68a2c3342 |
| 출처 메모 | uspto-grants-2011_09 |