Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine → 6-Methyl-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine | HCID 2777786 | — |
| 반응물 | 2-chloro-6-methyl-1H-1,3-benzodiazole | HCID 11629655 | — |
| 생성물 | 6-Methyl-2-[4-(3-trifluoromethylpyridin-2-yl)piperazin-1-yl]-1H-benzoimidazole | HCID 11661247 | — |
반응 단계
The reaction of 2-chloro-6-methyl-1H-benzoimidazole (0.261 g, 1.57 mmol, Example 14b) with 1-(3-trifluoromethylpyridin-2-yl)piperazine (0.54 g, 1.6 mmol, Maybridge) under the conditions of Example 3c afforded the title compound as a white solid. M.p. 216-217° C. MS (ESI, pos. ion) m/z: 362 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08026241B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-af20ab7c95eb4661b8c56d2455f52370 |
| 출처 메모 | uspto-grants-2011_09 |