2,5-Dichlorobenzimidazole → 6-Chloro-2-[4-(3,5-dichloropyridin-4-yl)piperazin-1-yl]-1H-benzoimidazole

반응식

Cl[C:2]1[NH:6][C:5]2[CH:7]=[CH:8][C:9]([Cl:11])=[CH:10][C:4]=2[N:3]=1.[Cl:12][C:13]1[CH:14]=[N:15][CH:16]=[C:17]([Cl:25])[C:18]=1[N:19]1[CH2:24][CH2:23][NH:22][CH2:21][CH2:20]1>>[Cl:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([N:22]3[CH2:23][CH2:24][N:19]([C:18]4[C:17]([Cl:25])=[CH:16][N:15]=[CH:14][C:13]=4[Cl:12])[CH2:20][CH2:21]3)[NH:3][C:4]=2[CH:10]=1

참가 물질

반응물 2

HCID 3354732,5-Dichlorobenzimidazole

HCID 27999841-(3,5-Dichloropyridin-4-yl)piperazine

생성물 1

HCID 578350816-Chloro-2-[4-(3,5-dichloropyridin-4-yl)piperazin-1-yl]-1H-benzoimidazole

실험 절차

The 2,5-dichloro-1H-benzoimidazole (0.37 g, 1.98 mmol, Example 20b) and 1-(3,5-dichloropyridin-4-yl)piperazine (0.46 g, 1.98 mmol, Maybridge) reacted under the conditions of Example 3c to give the title compound as a white solid. M.p. 258-260° C. MS (ESI, pos. ion) m/z: 382 (M+1).

출처 및 근거

ORD 기록: ord-b25e470e735e47739eba25f1e89b4650
출처 데이터셋: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08026241B2

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