2-chloro-6-(trifluoromethyl)-1H-benzimidazole → 2-[4-(8-Hydroxyquinolin-2-yl)piperazin-1-yl]-6-trifluoromethyl-1H-benzoimidazole
반응식
[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([N:12]1[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1)[CH:8]=[CH:7]2.Cl[C:19]1[NH:23][C:22]2[CH:24]=[C:25]([C:28]([F:31])([F:30])[F:29])[CH:26]=[CH:27][C:21]=2[N:20]=1>>[OH:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[C:9]([N:12]1[CH2:17][CH2:16][N:15]([C:19]3[NH:23][C:22]4[CH:24]=[C:25]([C:28]([F:31])([F:30])[F:29])[CH:26]=[CH:27][C:21]=4[N:20]=3)[CH2:14][CH2:13]1)[CH:8]=[CH:7]2참가 물질
3
실험 절차
The piperazine from step (b) above (0.329 g, 1.67 mmol) and 2-chloro-6-trifluoromethyl-1H-benzoimidazole (0.370 g, 1.67 mmol, Example 1c) reacted under the conditions of Example 3c to give the title compound. M.p. 191-193° C. MS (ESI, pos. ion) m/z: 414 (M+1).
출처 및 근거
- ORD 기록
- ord-0cf2b0dd7afe408b8c9f67e4867d6b67
- 출처 데이터셋
- uspto-grants-2011_09