참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethyl isocyanate | HCID 8022 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2-Benzothiazolamine, 6-bromo- | HCID 85149 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 1-(6-Bromo-2-benzothiazolyl)-3-ethylurea | HCID 21985564 | 94% |
반응 단계
A suspension of 2-amino-6-bromo-benzothiazole (6.12 g, 26.2 mmol), triethylamine (7.30 mL, 52.4 mmol, 2.0 eq), and ethyl isocyanate (4.15 mL, 52.4 mmol, 2.0 eq) in 50 mL toluene was heated at about 90° C. for about 15 hours. The precipitate was filtered off, washed with Et2O, and dried under vacuum to give the desired compound 7.39 g (94%). LC/MS 300.0 (M−1); LC retention time 3.01 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07091227B2 |
|---|
| 출처 데이터셋 | uspto-grants-2006_08 |
|---|
| ORD ID | ord-b5f2f4212b8240a4b4901953e91f7565 |
|---|
| 출처 메모 | uspto-grants-2006_08 |
|---|
