1-[3-(Trifluoromethyl)pyridin-2-yl]piperazine → HCID 178526651, 화합물
반응식
Cl[C:2]1[NH:6][C:5]2[CH:7]=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:9]=[C:10]([N+:11]([O-:13])=[O:12])[C:4]=2[N:3]=1.[F:18][C:19]([F:33])([F:32])[C:20]1[C:21]([N:26]2[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]2)=[N:22][CH:23]=[CH:24][CH:25]=1>>[N+:11]([C:10]1[C:4]2[NH:3][C:2]([N:29]3[CH2:30][CH2:31][N:26]([C:21]4[C:20]([C:19]([F:33])([F:18])[F:32])=[CH:25][CH:24]=[CH:23][N:22]=4)[CH2:27][CH2:28]3)=[N:6][C:5]=2[CH:7]=[C:8]([C:14]([F:17])([F:16])[F:15])[CH:9]=1)([O-:13])=[O:12]참가 물질
3
실험 절차
The benzoimidazole from step (c) above (1.5 g, 5.7 mmol) and 1-(3-trifluoromethylpyridin-2-yl)piperazine (1.8 g, 7.8 mmol, Matrix) reacted under the conditions of Example 3c to give the title compound as a orange solid. M.p. 192° C. MS (ESI, pos. ion) m/z: 461 (M+1).
출처 및 근거
- ORD 기록
- ord-29f39a33d861404eb3a81f5e3b503c92
- 출처 데이터셋
- uspto-grants-2011_09
- 특허 번호
- US08026241B2