2-chloro-6-(trifluoromethyl)-1H-benzimidazole → HCID 10475814, 화합물

HRID 912881노트

반응식

HRID 912881 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2([OH:14])[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1.Cl[C:16]1[NH:20][C:19]2[CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=[CH:24][C:18]=2[N:17]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2([OH:14])[CH2:13][CH2:12][N:11]([C:16]3[NH:20][C:19]4[CH:21]=[C:22]([C:25]([F:28])([F:27])[F:26])[CH:23]=[CH:24][C:18]=4[N:17]=3)[CH2:10][CH2:9]2)[CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 2

HCID 3379052-chloro-6-(trifluoromethyl)-1H-benzimidazoleHCID 100133914-(3-Chlorophenyl)piperidin-4-ol

생성물 1

HCID 10475814HCID 10475814, 화합물

실험 절차

4-(3-Chloro-phenyl)-piperidin-4-ol (0.25 g, 1.18 mmol, Aldrich) reacted with 2-chloro-6-trifluoromethyl-1H-benzoimidazole (0.26 g, 1.18 mmol, Example 1c) under the conditions of Example 94d to give the title compound as a white solid. M.p. 246.7-247.4° C. MS (ESI, pos. ion) m/z: 424 (M+1).

출처 및 근거

ORD 기록
ord-81bf0333f4b145cc8f156f60960dea14
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026241B2

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