1-(5,6-Dichloropyridin-3-yl)ethan-1-one → 2-(5,6-Dichloropyridin-3-yl)propan-2-ol

HRID 912934노트

반응식

HRID 912934 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([C:9](=[O:11])[CH3:10])[CH:5]=[N:6][C:7]=1[Cl:8].[CH3:12][Mg+].[Br-]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]([OH:11])([CH3:12])[CH3:10])[CH:5]=[N:6][C:7]=1[Cl:8]

참가 물질

3

반응물 2

HCID 101980061-(5,6-Dichloropyridin-3-yl)ethan-1-oneHCID 178418689HCID 178418689, 화합물

생성물 1

HCID 772303002-(5,6-Dichloropyridin-3-yl)propan-2-ol

실험 절차

1-(5,6-Dichloro-pyridin-3-yl)-ethanone from step (a) above (300 mg, 1.58 mmol) reacted with MeMgBr (0.79 mL, 2.4 mmol, 3.0 M in ether, Aldrich) under the conditions of Example 154b to give the title compound. MS (ESI, pos. ion) m/z: 206 (M+1).

출처 및 근거

ORD 기록
ord-0269234a008b44eaa2696bae66b1cc77
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026241B2

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