Triethylamine → 1-(6-Phenylacetylenyl-2-benzothiazolyl)-3-ethylurea

HRID 9130

반응식

HRID 9130 반응식
Br[C:2]1[CH:16]=[CH:15][C:5]2[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[S:8][C:4]=2[CH:3]=1.C(N(CC)CC)C.[C:24]1([C:30]#[CH:31])[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>CN(C=O)C.Cl[Pd](Cl)([P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1)[P](C1C=CC=CC=1)(C1C=CC=CC=1)C1C=CC=CC=1>[C:24]1([C:30]#[C:31][C:2]2[CH:16]=[CH:15][C:5]3[N:6]=[C:7]([NH:9][C:10]([NH:12][CH2:13][CH3:14])=[O:11])[S:8][C:4]=3[CH:3]=2)[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1

참가 물질

6

반응물 3

HCID 8471TriethylamineHCID 10821PhenylacetyleneHCID 219855641-(6-Bromo-2-benzothiazolyl)-3-ethylurea

생성물 1

HCID 219855451-(6-Phenylacetylenyl-2-benzothiazolyl)-3-ethylurea수율 8%

시약·촉매·용매 2

HCID 178418476HCID 178418476, 화합물촉매HCID 6228Dimethylformamide용매

실험 절차

A mixture of 1-(6-bromo-2-benzothiazolyl)-3-ethylurea, Pd(PPh3)2Cl2, triethylamine, and phenylacetylene in 1 mL of anhydrous DMF was reacted according to the procedure of Example 213 to give 0.008 g (8%) of the desired compound. LC/MS 322 (M+1); LC retention time 3.65 min.

후처리

  1. customwas reacted

출처 및 근거

ORD 기록
ord-6e34ac8687504305874573b2b52188a8
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07091227B2

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