3-Benzyloxy-6-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid → 5-(benzyloxy)-2-methylpyridin-4(1H)-one

HRID 913003

반응식

HRID 913003 반응식
[CH2:1]([O:8][C:9]1[C:14](=[O:15])[CH:13]=[C:12]([CH3:16])[NH:11][C:10]=1C(O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>CN(C=O)C>[CH2:1]([O:8][C:9]1[C:14](=[O:15])[CH:13]=[C:12]([CH3:16])[NH:11][CH:10]=1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

참가 물질

3

반응물 1

HCID 672824263-Benzyloxy-6-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid

생성물 1

HCID 63247195-(benzyloxy)-2-methylpyridin-4(1H)-one수율 77.1%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
120 °C

실험 절차

A suspension of 3-Benzyloxy-6-methyl-4-oxo-1,4-dihydro-pyridine-2-carboxylic acid (3.2 g, 0.02 mol) in DMF (30 ml) was heated in an oil bath at 120° C. for 8 hrs. The mixture was cooled to room temperature and the insoluble solid was filtered. The solid was washed with hexane and dried under vacuum for 16 hrs to give 5-benzyloxy-2-methyl-1H-pyridin-4-one (3.32 g, 77% yield).

후처리

  1. temperatureThe mixture was cooled to room temperature
  2. filtrationthe insoluble solid was filtered
  3. washThe solid was washed with hexane
  4. customdried under vacuum for 16 hrs

출처 및 근거

ORD 기록
ord-3fdb4b6614ac4bc1b9aaaebcbce71486
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026261B2

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