Methyl triflate → 5-Methoxy-4-azatricyclo[4.3.1.1,3,8]undec-4-ene

HRID 913050노트

반응식

HRID 913050 반응식
[CH:1]12[CH2:11][CH:6]3[CH2:7][CH:8]([CH2:10][CH:3]([NH:4][C:5]3=[O:12])[CH2:2]1)[CH2:9]2.O(C)S([C:17](F)(F)F)(=O)=O>C(Cl)Cl>[CH3:17][O:12][C:5]1[CH:6]2[CH2:11][CH:1]3[CH2:9][CH:8]([CH2:10][CH:3]([CH2:2]3)[N:4]=1)[CH2:7]2

참가 물질

4

반응물 2

HCID 9526Methyl triflateHCID 2866474-Azatricyclo[4.3.1.13,8]undecan-5-one

생성물 1

HCID 866090545-Methoxy-4-azatricyclo[4.3.1.1,3,8]undec-4-ene

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-azatricyclo[4.3.1.13,8]undecan-5-one 3-A (1.00 g, 6.05 mmol) in 10 mL methylene chloride was added methyl triflate (2.98 g, 3 eq) and the reaction was heated at reflux for 20 min, after which time all volatiles were removed under reduced pressure to afford crude 5-methoxy-4-azatricyclo[4.3.1.13,8]undec-4-ene 3-B which was used in the next step without further purification.

후처리

  1. temperaturethe reaction was heated
  2. temperatureat reflux for 20 min
  3. customafter which time all volatiles were removed under reduced pressure

출처 및 근거

ORD 기록
ord-f4452dc3a9414858b90eaa30610000e8
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026264B2

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