Allyl bromide → 3-Allyloxy-4-methoxybenzaldehyde

HRID 913125노트

반응식

HRID 913125 반응식
C(O[C:4]1[CH:5]=C(C=C[C:11]=1C)C=O)C.[OH:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[CH:17]=[O:18].C(Br)C=C.C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH2:5]([O:13][C:14]1[CH:15]=[C:16]([CH:19]=[CH:20][C:21]=1[O:22][CH3:23])[CH:17]=[O:18])[CH:4]=[CH2:11]

참가 물질

6

반응물 4

HCID 7841Allyl bromideHCID 11430Potassium CarbonateHCID 12127IsovanillinHCID 252420583-Ethoxy-4-methylbenzaldehyde

생성물 1

HCID 5341483-Allyloxy-4-methoxybenzaldehyde

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The title compound was prepared analogously to 3-ethoxy-4-methyl-benzaldehyde (intermediate E10) by reaction of 3-hydroxy-4-methoxy-benzaldehyde with allylbromide in DMF using K2CO3 as base (see also A. W. White, R. Almassy, A. H. Calvert, N. J. Curtin, R. J. Griffin, Z. Hostomsky, K. Maegley, D. R. Newell, S. Srinivasan and B. T. Golding J. Med. Chem. 2000, 43, 4084-4097).

출처 및 근거

ORD 기록
ord-9b2a613a32ef49a39cfc5cedf03cc61e
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026255B2

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