Triethylsilane → (3-chloro-4-{1-oxo-4,9-bis[(2,2,2-trifluoroethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetic acid
반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:35][C:36]([OH:38])=[O:37])[CH:5]=[CH:6][C:7]=1[N:8]1[CH:16](O)[C:15]2[C:14]([O:18][CH2:19][C:20]([F:23])([F:22])[F:21])=[C:13]3[CH:24]=[CH:25][CH:26]=[CH:27][C:12]3=[C:11]([O:28][CH2:29][C:30]([F:33])([F:32])[F:31])[C:10]=2[C:9]1=[O:34].C([SiH](CC)CC)C>FC(F)(F)C(O)=O>[Cl:1][C:2]1[CH:3]=[C:4]([CH2:35][C:36]([OH:38])=[O:37])[CH:5]=[CH:6][C:7]=1[N:8]1[C:9](=[O:34])[C:10]2[C:11]([O:28][CH2:29][C:30]([F:31])([F:32])[F:33])=[C:12]3[CH:27]=[CH:26][CH:25]=[CH:24][C:13]3=[C:14]([O:18][CH2:19][C:20]([F:21])([F:22])[F:23])[C:15]=2[CH2:16]1참가 물질
4
반응물 2
생성물 1
시약·촉매·용매 1
실험 절차
To a solution of (3-chloro-4-{1-hydroxy-3-oxo-4,9-bis[(2,2,2-trifluoroethyl)oxy]-1,3-dihydro-2H-benzo[f]isoindol-2-yl}phenyl)acetic acid (0.235 g, 0.42 mmol) in trifluoroacetic acid (5 ml) cooled to 0° C., was added triethylsilane (0.10 ml, 0.63 mmol). Stirring continued at 0° C. for 5 minutes and then the mixture was evaporated. The crude mixture was purified using MDAP. The clean fractions were evaporated to give a white solid. This was triturated with ether, the resulting white solid collected by filtration (0.008 g, 0.015 mmol). LC/MS: Rt=3.49, [MH]+548.