Acetyl chloride → Dimethyl acetylphosphonate

HRID 913206노트

반응식

[C:1](Cl)(=[O:3])[CH3:2].[CH3:5][O:6][P:7]([O:10]C)[O:8][CH3:9]>>[C:1]([P:7](=[O:10])([O:8][CH3:9])[O:6][CH3:5])(=[O:3])[CH3:2]

참가 물질

반응물 2

HCID 6367Acetyl chloride

HCID 8472Trimethyl phosphite

생성물 1

HCID 2785315Dimethyl acetylphosphonate

반응 조건

온도: 80 °C

실험 절차

Acetyl chloride (7.85 ml, 110 mmol) was cooled to 0° C. and stirred. Trimethylphosphite (11.8 ml, 100 mmol) was added drop-wise over one hour while the cooling was maintained. The mixture was then heated to 80° C. for 5 minute to remove un-reacted acetyl chloride (the flow of argon accelerates the process). The crude product was used in the next step without additional purification (theoretical yield is 15.2 g).

후처리

temperaturewas maintained
customto remove
customun-reacted acetyl chloride (the flow of argon
customThe crude product was used in the next step without additional purification (theoretical yield is 15.2 g)

출처 및 근거

ORD 기록: ord-8a98fc38509e461d81c3130a305f5db4
출처 데이터셋: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08026278B2

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