Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Stavudine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | HCID 10572932 | HCID 10572932 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 생성물 | Stavudine | HCID 18283 | 79% |
반응 단계
In the above synthesis, 3′,5′-di-O-mesylthymidine is first treated with sodium hydroxide in refluxing water for 2 hours and the resultant 3,4-anhydrothymidine is treated with potassium t-butoxide in dimethyl sulfoxide (DMSO) at room temperature for 2 hrs. The reaction mixture is neutralized, evaporated to dryness and after a series of manipulations which included extraction, declourization, precipitation and recrystallization, gave Stavudine in 79% yield and an overall yield of 56%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08026356B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-b60f983729914b91a099b1bb67103bf9 |
| 출처 메모 | uspto-grants-2011_09 |