참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Stavudine | HCID 18283 | — |
| 반응물 | 2(1H)-Pyrimidinone, tetrahydro-1,3-dimethyl- | HCID 81646 | — |
| 용매 | Acetone | HCID 180 | — |
| 생성물 | Stavudine DMPU | HCID 86625622 | 87.5% |
반응 단계
Crude Stavudine (25 g, 97.7% pure, 0.1116 mole), DMPU (37.5 g, 1.5 parts) are added to acetone (50 ml) and heated to 56° C. for dissolution. The obtained solution is stirred for 15 min. at 56° C. and cooled to 6-8° C. The precipitated product is filtered, washed with acetone and dried to give 34.4 g of Stavudine DMPU solvate (87.5%) with a chromatographic purity 99.93%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08026356B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_09 |
|---|
| ORD ID | ord-2bdc41f217664607a37266af142ffb4a |
|---|
| 출처 메모 | uspto-grants-2011_09 |
|---|
