참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Cesium carbonate | HCID 10796 | — |
| 반응물 | 2-Bromopropanamide | HCID 101118 | — |
| 반응물 | 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile | HCID 24985632 | — |
| 생성물 | 2-[4-Chloro-5-cyano-2-(difluoromethyl)-1H-indol-1-yl]propanamide | HCID 24985805 | — |
반응 단계
Synthesized as described in Example 4 using 4-chloro-2-(difluoromethyl)-1H-indole-5-carbonitrile, 2-bromo-propionamide (2 eq) and Cs2CO3 (2 eq). After heating at 90° C. for 4 h, additional 2-bromo-propionamide (2 eq) and Cs2CO3 (2 eq) were added and the reaction mixture heated at 110° C. for 15 h: MS (ES) m/z 298 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08026262B2 |
|---|
| 출처 데이터셋 | uspto-grants-2011_09 |
|---|
| ORD ID | ord-615baa6b5e3d4f3482bd33eadea97978 |
|---|
| 출처 메모 | uspto-grants-2011_09 |
|---|
