Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 913569생성일: 2026년 10월 26일
5-bromo-4-chloro-2-ethyl-1H-benzimidazole → 4-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile
https://huagongshe.com/reaction/913569
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 5-bromo-4-chloro-2-ethyl-1H-benzimidazole | HCID 57800158 | — |
| 반응물 | HCID 178418546 | HCID 178418546 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 4-chloro-2-ethyl-1H-benzimidazole-5-carbonitrile | HCID 67404902 | 35.5% |
반응 단계
5-Bromo-4-chloro-2-ethyl-1H-benzimidazole (0.050 g, 0.192 mmol) and CuCN (0.030 g, 0.576 mmol) were combined in NMP (3 mL) and heated to 220° C. for 20 min in a microwave. The cooled mixture was partitioned between Et2O and water. The organic portion was washed with brine, dried (Na2SO4), filtered, and concentrated in vacuo. Purification (SiO2, EtOAc/hexanes) afforded the title compound (0.014 g): MS (ESI) m/z 206 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US08026262B2 |
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| 출처 데이터셋 | uspto-grants-2011_09 |
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| ORD ID | ord-726f7b16115b4859b4127be5efff1667 |
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| 출처 메모 | uspto-grants-2011_09 |
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