4-(Chloromethyl)-1,3-thiazole hydrochloride → 4-Chloro-1-(1,3-thiazol-4-ylmethyl)-2-(trifluoromethyl)-1H-benzimidazole-5-carbonitrile

HRID 913580노트

반응식

HRID 913580 반응식
[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([F:14])([F:13])[F:12])[NH:7][C:6]=2[CH:5]=[CH:4][C:3]=1[C:15]#[N:16].Cl.Cl[CH2:19][C:20]1[N:21]=[CH:22][S:23][CH:24]=1>>[Cl:1][C:2]1[C:10]2[N:9]=[C:8]([C:11]([F:12])([F:13])[F:14])[N:7]([CH2:19][C:20]3[N:21]=[CH:22][S:23][CH:24]=3)[C:6]=2[CH:5]=[CH:4][C:3]=1[C:15]#[N:16]

참가 물질

3

반응물 2

HCID 27632894-(Chloromethyl)-1,3-thiazole hydrochlorideHCID 674045324-chloro-2-(trifluoromethyl)-1H-benzimidazole-5-carbonitrile

생성물 1

HCID 674054464-Chloro-1-(1,3-thiazol-4-ylmethyl)-2-(trifluoromethyl)-1H-benzimidazole-5-carbonitrile

실험 절차

Synthesized as described in Example 197B from 4-chloro-2-(trifluoromethyl)-1H-benzimidazole-5-carbonitrile and 4-(chloromethyl)-1,3-thiazole hydrochloride: MS (ESI) m/z 343 (M+1).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-ab29d0cacd0b40c1bc2854582450a3f5
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026262B2

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