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Bromine → HCID 57800275, 화합물

HRID 913612
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HRID 913612 반응식
[Cl:1][C:2]1[C:3]([CH3:15])=[C:4]([NH:8][C:9](=[O:14])[C:10]([CH3:13])([CH3:12])[CH3:11])[CH:5]=[CH:6][CH:7]=1.[Br:16]Br>CC(O)=O>[Br:16][C:7]1[CH:6]=[CH:5][C:4]([NH:8][C:9](=[O:14])[C:10]([CH3:11])([CH3:12])[CH3:13])=[C:3]([CH3:15])[C:2]=1[Cl:1]
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참가 물질

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HCID 24408BromineHCID 4204423N-(3-chloro-2-methylphenyl)-2,2-dimethylpropanamide

생성물 1

HCID 57800275HCID 57800275, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

N-(3-Chloro-2-methylphenyl)-2,2-dimethylpropanamide (0.5 g, 2.2 mmol) and bromine (1.4 g, 8.8 mmol) were combined in AcOH (25 mL) at rt for 2 h. The residue resulting from concentration was purified by flash chromatography (20-60% EtOAc-hexanes gradient) to afford the title compound: MS (ES) m/z 305 (M+1).

후처리

  1. customThe residue resulting from concentration
  2. customwas purified by flash chromatography (20-60% EtOAc-hexanes gradient)

출처 및 근거

ORD 기록
ord-7db35f6a463a4c7b84916dd8cc1c01cc
출처 데이터셋
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08026262B2

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