Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole → 1-{[5-(3,5-Difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-4,5-dicarbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole | HCID 43120209 | — |
| 반응물 | 2-propyl-1H-indole-4,5-dicarbonitrile | HCID 57800367 | — |
| 생성물 | 1-{[5-(3,5-Difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-4,5-dicarbonitrile | HCID 57800089 | — |
반응 단계
Synthesized as described in Example 4 from 2-propyl-1H-indole-4,5-dicarbonitrile and 3-(chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole: 1H NMR (400 MHz, DMSO-d6) δ 8.15 (s, 1 H), 7.85 (d, J=8.5 Hz, 1 H), 7.75-7.62 (m, 4 H), 5.94 (s, 2 H), 3.06 (t, 2 H), 1.77-1.65 (m, 2 H), 0.95 (t, J=7.3 Hz, 3 H): MS (ES) m/z 404 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08026262B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-b46db787c5cc46e8af13520666912c1b |
| 출처 메모 | uspto-grants-2011_09 |