3-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole → 1-{[5-(3,5-Difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-4,5-dicarbonitrile

HRID 913617

반응식

HRID 913617 반응식
[CH2:1]([C:4]1[NH:5][C:6]2[C:11]([CH:12]=1)=[C:10]([C:13]#[N:14])[C:9]([C:15]#[N:16])=[CH:8][CH:7]=2)[CH2:2][CH3:3].Cl[CH2:18][C:19]1[N:23]=[C:22]([C:24]2[CH:29]=[C:28]([F:30])[CH:27]=[C:26]([F:31])[CH:25]=2)[O:21][N:20]=1>>[F:30][C:28]1[CH:29]=[C:24]([C:22]2[O:21][N:20]=[C:19]([CH2:18][N:5]3[C:6]4[C:11](=[C:10]([C:13]#[N:14])[C:9]([C:15]#[N:16])=[CH:8][CH:7]=4)[CH:12]=[C:4]3[CH2:1][CH2:2][CH3:3])[N:23]=2)[CH:25]=[C:26]([F:31])[CH:27]=1

참가 물질

3

반응물 2

HCID 431202093-(Chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazoleHCID 578003672-propyl-1H-indole-4,5-dicarbonitrile

생성물 1

HCID 578000891-{[5-(3,5-Difluorophenyl)-1,2,4-oxadiazol-3-yl]methyl}-2-propyl-1H-indole-4,5-dicarbonitrile

실험 절차

Synthesized as described in Example 4 from 2-propyl-1H-indole-4,5-dicarbonitrile and 3-(chloromethyl)-5-(3,5-difluorophenyl)-1,2,4-oxadiazole: 1H NMR (400 MHz, DMSO-d6) δ 8.15 (s, 1 H), 7.85 (d, J=8.5 Hz, 1 H), 7.75-7.62 (m, 4 H), 5.94 (s, 2 H), 3.06 (t, 2 H), 1.77-1.65 (m, 2 H), 0.95 (t, J=7.3 Hz, 3 H): MS (ES) m/z 404 (M+1).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-b46db787c5cc46e8af13520666912c1b
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026262B2

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