2-Bromo-5-(chloromethyl)furan → 1-[(5-Bromo-2-furanyl)methyl]-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 913698

반응식

HRID 913698 반응식
[CH:1]1([C:4]2[NH:5][C:6]3[C:11]([CH:12]=2)=[C:10]([C:13]([F:16])([F:15])[F:14])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=3)[CH2:3][CH2:2]1.[Br:19][C:20]1[O:21][C:22]([CH2:25]Cl)=[CH:23][CH:24]=1>>[Br:19][C:20]1[O:21][C:22]([CH2:25][N:5]2[C:6]3[C:11](=[C:10]([C:13]([F:14])([F:15])[F:16])[C:9]([C:17]#[N:18])=[CH:8][CH:7]=3)[CH:12]=[C:4]2[CH:1]2[CH2:2][CH2:3]2)=[CH:23][CH:24]=1

참가 물질

3

반응물 2

HCID 122078912-Bromo-5-(chloromethyl)furanHCID 674044722-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

생성물 1

HCID 674049931-[(5-Bromo-2-furanyl)methyl]-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

실험 절차

Synthesized as described in Example 4 using 2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 165A) and 2-bromo-5-(chloromethyl)furan (Example 310B): MS (ES) m/z 409 (M+1) and 411 (M+1, isotope).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-82419d1eadb14e1bbfa788b4196d2a5e
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026262B2

연결된 노트

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