Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(3,5-Difluorophenyl)boronic acid → 1-{[2-(3,5-Difluorophenyl)-1,3-thiazol-4-yl]methyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (3,5-Difluorophenyl)boronic acid | HCID 2734338 | — |
| 반응물 | 1-[(2-Bromo-1,3-thiazol-4-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67404358 | — |
| 생성물 | 1-{[2-(3,5-Difluorophenyl)-1,3-thiazol-4-yl]methyl}-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile | HCID 67406112 | — |
반응 단계
Synthesized as described in Example 310D using 1-[(2-bromo-1,3-thiazol-4-yl)methyl]-2-methyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 311B) and [3,5-difluorophenyl]boronic acid: MS (ES) m/z 434 (M+1).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08026262B2 |
| 출처 데이터셋 | uspto-grants-2011_09 |
| ORD ID | ord-6db4fbcf0f77411aa23dd4a9b3f24e7a |
| 출처 메모 | uspto-grants-2011_09 |