3,5-Bis-trifluoromethylphenylboronic acid → 1-({5-[3,5-bis(Trifluoromethyl)phenyl]-2-furanyl}methyl)-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

HRID 913750

반응식

HRID 913750 반응식
Br[C:2]1[O:6][C:5]([CH2:7][N:8]2[C:16]3[C:11](=[C:12]([C:19]([F:22])([F:21])[F:20])[C:13]([C:17]#[N:18])=[CH:14][CH:15]=3)[CH:10]=[C:9]2[CH:23]2[CH2:25][CH2:24]2)=[CH:4][CH:3]=1.[F:26][C:27]([F:42])([F:41])[C:28]1[CH:29]=[C:30](B(O)O)[CH:31]=[C:32]([C:34]([F:37])([F:36])[F:35])[CH:33]=1>>[F:26][C:27]([F:41])([F:42])[C:28]1[CH:29]=[C:30]([C:2]2[O:6][C:5]([CH2:7][N:8]3[C:16]4[C:11](=[C:12]([C:19]([F:20])([F:22])[F:21])[C:13]([C:17]#[N:18])=[CH:14][CH:15]=4)[CH:10]=[C:9]3[CH:23]3[CH2:25][CH2:24]3)=[CH:4][CH:3]=2)[CH:31]=[C:32]([C:34]([F:35])([F:36])[F:37])[CH:33]=1

참가 물질

3

반응물 2

HCID 1562653,5-Bis-trifluoromethylphenylboronic acidHCID 674049931-[(5-Bromo-2-furanyl)methyl]-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

생성물 1

HCID 866207151-({5-[3,5-bis(Trifluoromethyl)phenyl]-2-furanyl}methyl)-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile

실험 절차

Synthesized as described in Example 310D using (1-[(5-bromo-2-furanyl)methyl]-2-cyclopropyl-4-(trifluoromethyl)-1H-indole-5-carbonitrile (Example 310C) and [3,5-bis(trifluoromethyl)phenyl]boronic acid: MS (ES) m/z 543 (M+1).

후처리

  1. customSynthesized

출처 및 근거

ORD 기록
ord-d064744397af4856b764bb9b779ca213
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026262B2

연결된 노트

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