2-Bromo-4-chloroaniline → 7-bromo-5-chloro-1H-indole

HRID 913963

반응식

HRID 913963 반응식
[Br:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[CH:5][C:3]=1[NH2:4].Br[C:11]1C=C(C(F)(F)F)C=C2[C:19]=1NC=C2>>[Br:1][C:2]1[CH:8]=[C:7]([Cl:9])[CH:6]=[C:5]2[C:3]=1[NH:4][CH:19]=[CH:11]2

참가 물질

3

반응물 2

HCID 701102-Bromo-4-chloroanilineHCID 575461357-Bromo-5-(trifluoromethyl)-1H-indole

생성물 1

HCID 247295047-bromo-5-chloro-1H-indole

실험 절차

Made from 2-bromo-4-chloroaniline using the method for 7-bromo-5-(trifluoromethyl)-1H-indole. 1H-NMR (CDCl3, 400 MHz) δ 8.32 (bs, 1H), 7.55 (d, J=1.2 Hz, 1H), 7.55 (d, J=1.8 Hz, 1H), 7.27 (t, J=3.0 Hz, 1H), 6.56 (dd, J=3.3, 2.3 Hz, 1H). LC/MS (HPLC method 4): tR=3.07 min, 229.95(MH)+.

출처 및 근거

ORD 기록
ord-e040ca7804184ab1b9c3e5314c2074ef
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026257B2

연결된 노트

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