Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethylamine → N1-[3-(2-{[(Ethylamino)carbonyl]amino}-1,3-benzothiazol-6-yl)-3-oxopropyl]-2,5-difluorobenzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | 2,5-Difluorobenzoyl chloride | HCID 588082 | — |
| 반응물 | 1-(6-(3-Aminopropanoyl)-2-benzothiazolyl)-3-ethylurea | HCID 21985556 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 생성물 | N1-[3-(2-{[(Ethylamino)carbonyl]amino}-1,3-benzothiazol-6-yl)-3-oxopropyl]-2,5-difluorobenzamide | HCID 21985558 | 22% |
반응 단계
Similar to the synthesis of Example 249, a mixture of 1-(6-(3-aminopropanoyl)-2-benzothiazolyl)-3-ethylurea, triethylamine and 2,5-difluorobenzoyl chloride in DMF was reacted to give the desired compound 0.019 g (22%). LC/MS 433.0 (M+1); LC retention time 2.94 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091227B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-f1d1a30eab97407f8e26262ae5a1d46f |
| 출처 메모 | uspto-grants-2006_08 |