4′-Fluoro-4-(2-{2-[(2-tert-butyl-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}ethoxy)biphenyl-3-carboxylic acid (170 mg) obtained in Example 93-1 and morpholine (43 mg) were dissolved in dichloromethane (2 mL), N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) hydrochloride (94 mg) and 1-hydroxybenztriazole (HOBt) monohydrate (75 mg) were successively added, and the mixture was stirred at room temperature for 6 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; hexane:ethyl acetate=2:1) to give the title compound (180 mg) as a colorless oil.
