Trifluoroacetic acid → 2-{[4-(2-{[3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl]amino}ethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid

HRID 914397

반응식

HRID 914397 반응식
C([O:5][C:6](=[O:20])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][C:17](O)=O)[N:15]=1)([CH3:9])[CH3:8])(C)(C)C.[Cl:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:32]=[C:31]([NH2:33])[N:30]([CH3:34])[N:29]=2)=[CH:24][CH:23]=1.FC(F)(F)C(O)=O>ClCCl>[Cl:21][C:22]1[CH:23]=[CH:24][C:25]([C:28]2[CH:32]=[C:31]([NH:33][CH2:17][CH2:16][C:14]3[N:15]=[C:11]([S:10][C:7]([CH3:8])([CH3:9])[C:6]([OH:5])=[O:20])[S:12][CH:13]=3)[N:30]([CH3:34])[N:29]=2)=[CH:26][CH:27]=1

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 27353043-(4-Chlorophenyl)-1-Methyl-1H-Pyrazol-5-AmineHCID 59759443HCID 59759443, 화합물

생성물 1

HCID 597588902-{[4-(2-{[3-(4-chlorophenyl)-1-methyl-1H-pyrazol-5-yl]amino}ethyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The compound obtained using {2-[(2-tert-butoxy-1,1-dimethyl-2-oxoethyl)thio]-1,3-thiazol-4-yl}acetic acid synthesized in Example 3 and 3-(4-chlorophenyl)-1-methyl-1H-pyrazole-5-amine as starting materials and by operations similar to those of Example 242-1 and Example 242-2 was treated with dichloromethane and trifluoroacetic acid, and the mixture was stirred at room temperature for 12 hr. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; chloroform:methanol=20:1) to give the title compound.

후처리

  1. customThe compound obtained
  2. concentrationThe reaction mixture was concentrated under reduced pressure
  3. customthe residue was purified by silica gel chromatography (elution solvent; chloroform:methanol=20:1)

출처 및 근거

ORD 기록
ord-c80070c6982d4d75992c1e9493fe8b4b
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026370B2

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