4-Chloro-2-methylthiopyrimidine → 4-Ethoxy-2-(methylsulfanyl)pyrimidine

HRID 914408노트

반응식

HRID 914408 반응식
Cl[C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1.[O-:10][CH2:11][CH3:12].[Na+]>C(O)C>[CH2:11]([O:10][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([S:8][CH3:9])[N:3]=1)[CH3:12]

참가 물질

4

반응물 2

HCID 971134-Chloro-2-methylthiopyrimidineHCID 2723922Sodium ethoxide

생성물 1

HCID 2781014-Ethoxy-2-(methylsulfanyl)pyrimidine수율 94.4%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
60 °C

실험 절차

4-Chloro-2-(methylthio)pyrimidine (3.0 g) was dissolved in ethanol (30 mL), sodium ethoxide (2.54 g) was added, and the mixture was stirred at 60° C. for 10 hr. The reaction mixture was cooled, and the solvent was concentrated under reduced pressure. Water was added, and the mixture was extracted with diethyl ether. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure to give the title compound (3.0 g) as a slightly yellow oil.

후처리

  1. temperatureThe reaction mixture was cooled
  2. concentrationthe solvent was concentrated under reduced pressure
  3. additionWater was added
  4. extractionthe mixture was extracted with diethyl ether
  5. washThe organic layer was washed with saturated brine
  6. dry with materialdried over anhydrous sodium sulfate
  7. customThe solvent was evaporated under reduced pressure

출처 및 근거

ORD 기록
ord-3989c979b91544b78c60ec5ed8ec308c
출처 데이터셋
uspto-grants-2011_09
특허 번호
US08026370B2

반응 노트

불러오는 중…