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Trifluoroacetic acid → 2-[(4-{3-[(5-Cyanopyridin-2-yl)(heptyl)amino]propyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid trifluoroacetate

HRID 914431
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HRID 914431 반응식
C([O:5][C:6](=[O:20])[C:7]([S:10][C:11]1[S:12][CH:13]=[C:14]([CH2:16][CH2:17][CH2:18][NH2:19])[N:15]=1)([CH3:9])[CH3:8])(C)(C)C.Cl[C:22]1[CH:29]=[CH:28][C:25]([C:26]#[N:27])=[CH:24][N:23]=1.[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33]>ClCCl>[F:30][C:31]([F:36])([F:35])[C:32]([OH:34])=[O:33].[C:26]([C:25]1[CH:28]=[CH:29][C:22]([N:19]([CH2:13][CH2:14][CH2:16][CH2:17][CH2:18][CH2:31][CH3:32])[CH2:18][CH2:17][CH2:16][C:14]2[N:15]=[C:11]([S:10][C:7]([CH3:8])([CH3:9])[C:6]([OH:5])=[O:20])[S:12][CH:13]=2)=[N:23][CH:24]=1)#[N:27]
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참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 51520946-Chloro-3-pyridinecarbonitrileHCID 597590072-{[4-(3-Aminopropyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester

생성물 1

HCID 674010822-[(4-{3-[(5-Cyanopyridin-2-yl)(heptyl)amino]propyl}-1,3-thiazol-2-yl)thio]-2-methylpropionic acid trifluoroacetate

시약·촉매·용매 1

HCID 6344Dichloromethane
용매

실험 절차

A compound obtained using 2-{[4-(3-aminopropyl)-1,3-thiazol-2-yl]thio}-2-methylpropionic acid tert-butyl ester synthesized in Example 33 and 6-chloronicotinonitrile as starting materials and by operations similar to those of Example 265-1 and Example 265-2 was treated with dichloromethane and trifluoroacetic acid, and the mixture was stirred at room temperature for 12 hr. The reaction solution was concentrated under reduced pressure, and the residue was purified by silica gel chromatography (elution solvent; chloroform:methanol=50:1) to give the title compound.

후처리

  1. customA compound obtained
  2. concentrationThe reaction solution was concentrated under reduced pressure
  3. customthe residue was purified by silica gel chromatography (elution solvent; chloroform:methanol=50:1)

출처 및 근거

ORD 기록
ord-77926d35954c409bb8de8cd1aa18a51b
출처 데이터셋
uspto-grants-2011_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08026370B2

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