tert-Butyl bromoacetate → {2-[(2-Tert-butoxy-2-oxoethyl)thio]-1,3-thiazol-4-yl}acetic acid ethyl ester

반응식

[CH2:1]([O:3][C:4](=[O:12])[CH2:5][C:6]1[N:7]=[C:8]([SH:11])[S:9][CH:10]=1)[CH3:2].[C:13]([O:17][C:18](=[O:21])[CH2:19]Br)([CH3:16])([CH3:15])[CH3:14]>>[CH2:1]([O:3][C:4](=[O:12])[CH2:5][C:6]1[N:7]=[C:8]([S:11][CH2:19][C:18]([O:17][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:21])[S:9][CH:10]=1)[CH3:2]

참가 물질

반응물 2

HCID 79177tert-Butyl bromoacetate

HCID 178470768HCID 178470768, 화합물

생성물 1

HCID 67398495{2-[(2-Tert-butoxy-2-oxoethyl)thio]-1,3-thiazol-4-yl}acetic acid ethyl ester

실험 절차

The title compound was obtained by an operation similar to that of Example 2 and using (2-mercapto-1,3-thiazol-4-yl)acetic acid ethyl ester synthesized in Example 1 and bromoacetic acid tert-butyl ester to give {2-[(2-tert-butoxy-2-oxoethyl)thio]-1,3-thiazol-4-yl}acetic acid ethyl ester, followed by sequential operations similar to those of Examples 3, 4, 5, 6, 7 and 162.

출처 및 근거

ORD 기록: ord-1bbb80d0c996408696bb8bc5010c016d
출처 데이터셋: uspto-grants-2011_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08026370B2

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