Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 1-(6-(4-Pyrazolyl)-2-benzothiazolyl)-3-ethylurea
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | N,N-Dimethylformamide--water (1/1) | HCID 21962138 | — |
| 반응물 | 1-(6-Bromo-2-benzothiazolyl)-3-ethylurea | HCID 21985564 | — |
| 반응물 | 1-(6-(3-Aminophenyl)-2-benzothiazolyl)-3-ethylurea | HCID 21985575 | — |
| 촉매 | HCID 178418397 | HCID 178418397 | — |
| 생성물 | 1-(6-(4-Pyrazolyl)-2-benzothiazolyl)-3-ethylurea | HCID 21985578 | 30% |
반응 단계
Similar to the synthesis of 1-(6-(3-aminophenyl)-2-benzothiazolyl)-3-ethylurea, a mixture of 4-pyrazolylboronic pinacolate, 1-(6-bromo-2-benzothiazolyl)-3-ethylurea, sodium carbonate, and Pd(PPh3)4 in DMF/water mixed solvent was reacted to give the desired compound 0.543 g (30%). LC/MS 288.2 (M+1); LC retention time 2.61 min.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07091227B2 |
| 출처 데이터셋 | uspto-grants-2006_08 |
| ORD ID | ord-a5f3ce06d6ac4f33ac47c498605c9889 |
| 출처 메모 | uspto-grants-2006_08 |